Just as a note, sickle cell is not caused by a pathogen. It's an inherited trait like eye color. It's genetic. It's a mutation in the hemoglobin gene that somehow confers resistance to malaria.
It causes other issues for the individual, but nothing is perfect. All of our components cause issues that eventually lead to our deaths.
In any case, sickle cell is selected for by malaria mosquitos in third world countries in africa.
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